Liver Awareness Month

October is not just the month of pumpkins and Halloween; it’s also Liver Awareness Month, a time dedicated to shedding light on the importance of liver health! The liver plays a crucial role in our bodies, yet many people remain unaware of the silent threats that can affect it, particularly chronic liver diseases. In this blog post, we will delve into the significance of Liver Awareness Month, the prevalence of chronic liver diseases, with a focus on Non-Alcoholic Fatty Liver Disease (NAFLD), the challenges of diagnosing silent liver diseases, and the importance of raising awareness, finding, diagnosing, and treating patients effectively.

The Silent Threat: Chronic Liver Diseases

Chronic liver diseases are a growing global health concern. Often referred to as the “silent killers,” these conditions can quietly progress over many years without any noticeable symptoms until the damage is severe. The liver is essential for metabolizing nutrients, filtering toxins, and producing proteins, making its health vital for overall well-being.

One of the most common chronic liver diseases is Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD (or MAFLD) is characterized by the accumulation of excess fat in the liver cells of people who drink little to no alcohol. It is often associated with obesity, diabetes, and metabolic syndrome. NAFLD can progress to a more severe form known as Non-Alcoholic Steatohepatitis (NASH or MASH), which includes liver inflammation and can lead to cirrhosis, liver failure, and even liver cancer.

The Challenge of Diagnosing Silent Liver Diseases

One of the main challenges in addressing chronic liver diseases is the difficulty in diagnosing them early. Since these conditions typically manifest without symptoms until significant liver damage has occurred, many individuals are unaware of their condition until late later disease stages.

Standard biomarkers of liver injury can be valuable tools to indicate a problem with the liver, but are non-specific and may perform poorly in the early detecting of NAFLD and NASH. Therefore, it is essential to complement the use of standard biomarkers in order to increase the accuracy for detecting and stratifying NAFLD and NASH patients at an early stage, before advancements into end stage liver disease.

A Patient’s Perspective

To understand the challenges of diagnosing silent liver diseases better, let’s hear from one NAFLD patient:

“I had always thought I was in good health until a routine check-up revealed something unexpected. My doctor told me I had a fatty liver with possible inflammation and fibrosis, but I had no symptoms at all. It was purely coincidental that we found this out. I’m still uncertain about where I stand in the disease progression and what steps I need to take. It’s been quite confusing, not knowing whether I should be worried or if there’s something I can do to improve my liver health.”

Liver Awareness Month serves as a reminder of the importance of liver health. It is a crucial time to educate the public about chronic liver diseases, their risk factors, and the significance of early detection. Community awareness campaigns, healthcare professionals, and patient organizations play a vital role in spreading knowledge about liver health. Additionally, finding patients with silent liver diseases requires proactive efforts. Routine health check-ups should include liver function tests for those at risk, such as individuals with obesity, diabetes, or metabolic syndrome. Educating primary care providers about the importance of early screening can also lead to more timely diagnoses.

Here, measuring Keratin 18 (K18) has been shown to be a sensitive indicator of NAFLD and NASH, can aid in NAFLD staging, increase the accuracy of biomarker panels for fibrotic NASH, and follow up treatment effect on the liver.

Early diagnosis and intervention are key to managing chronic liver diseases effectively. While there is no specific medication for NAFLD or NASH as of today, lifestyle changes like weight loss, a balanced diet, exercise, and managing underlying conditions like diabetes can slow or even reverse liver damage in some cases.

Liver Awareness Month in October is a crucial opportunity to raise awareness about the silent threats posed by chronic liver diseases like NAFLD and NASH. By increasing public knowledge, advocating for routine testing in at-risk individuals, and promoting a healthy lifestyle, we can work together to prevent liver diseases from progressing to irreversible stages. Remember, early detection and intervention can make all the difference in preserving liver health and improving the lives of those affected. Let’s make liver health a priority this October and beyond!

Read more on how the M30 Apoptosense® ELISA can aid in diagnosing NASH and fibrotic NASH

Read more on how the M30 Apoptosense® ELISA can aid in diagnosing pediatric NASH

Read more on how the K18 assays can help in NAFLD clinical trials

Reda Elkhatib