Total cell death
M65® ELISA, M65 EpiDeath® ELISA and M65 EpiRat™ ELISA
Cell death occurs by two principal mechanisms, necrosis and apoptosis. While apoptosis is a naturally occurring process, essential in the development and regeneration of tissue and organs, necrosis is a pathologic process resulting from progressive cell injury.
Necrosis is a cell death mechanism normally activated by factors external to the cell, such as a disease, toxicity or tissue trauma, that cause severe damage to the cell. Recently, scientists have also observed programmed necrosis. Cells undergoing necrosis are disrupted and release intracellular contents into the extracellular space in an uncontrolled manner, usually triggering an inflammatory response in the surrounding tissue.