Drug-Induced Liver Injury
Drug-Induced Liver Injury (DILI) is one of the most common reason for acute liver failure and a condition that may require liver transplantation and in some cases even has fatal outcomes. Today, DILI has implications in both the development of new drugs and in clinics due to toxicity of existing drugs on the market.
Many drugs, e.g. acetaminophen, statins and anti-infective substances, have toxic effects when administered in wrong doses. As a result, DILI is a leading cause of drug withdrawal from the market. Furthermore, acetaminophen overdose is a common reason for hospitalization and the most frequent cause of hepatotoxicity, showing a high morbidity and mortality.