M30 Apoptosense® ELISA and M30 CytoDeath™ ELISA
Apoptosis is a programmed and controlled cell death mechanism that becomes activated by either intracellular or extracellular stimuli. This is a process normal to the body, serving to eliminate damaged or senescent cells and to remodel cells and tissue during development . In other words, apoptosis serves many normal functions and is not necessarily associated with cell injury.
However, many pathological states also result in apoptosis. This is the body’s own way of eliminating damaged and dangerous cells without causing collateral tissue damage, thus minimizing the effects of a disease or exposure to a toxic substance.
The activation of the apoptotic pathways results in DNA fragmentation, membrane blebbing and the break down of intracellular compontents, such as the protein keratin 18 (K18), and ultimately cell fragmentation into apoptotic bodies.