The VLVbio K18 assays in Clinical Research

K18 IN CLINICAL RESEARCH K18 IN CLINICAL RESEARCH K18 IN CLINICAL RESEARCH K18 IN CLINICAL RESEARCH K18 IN CLINICAL RESEARCH 

Screening of Anticancer Agents in 2D and 3D cell cultures

By using the M30 Apoptosense® ELISA and the M65® ELISA, the efficacy of therapy can be demonstrated during the course of treatment. In contrast to other techniques or biomakers, which monitor tumour size and thus change slowly over the time-course of treatment, the rate of cell death is an immediate response of successful therapy indicated within hours or days from induction.

Short time elevations in caspase-cleave keratin 18 (ccK18) and total keratin 18 (K18), measured with M30 Apoptosense® ELISA and the M65® ELISA respectively, during therapy are indicative of therapy response

Persistently ccK18 and K18 levels after therapy indicate progressive disease

Relative concentrations of ccK18 and K18 provide information regarding to the mechanism of the drug, i.e. apoptosis or necrosis

Stratification of Patients

The M30 Apoptosense® ELISA and the M65® ELISA can be useful tools when assessing progression of disease and prognosis among cancer patients or study subjects, and when discriminating between healthy individuals and patients with cancer.

The M30 Apoptosense® ELISA and the M65® ELISA can be used as tools to evaluate the prognosis among cancer patients by quantifying levels of K18

The M30 Apoptosense® ELISA and the M65® ELISA could be useful when stratifying cancer patients according to progression of disease

The M30 Apoptosense® ELISA can be of value when discriminating between cancer patients and healthy individuals

Order the VLVbio K18 assays from your local distributor