The VLVbio K18 assays in Drug Development
K18 IN DRUG DEVELOPMENT K18 IN DRUG DEVELOPMENT K18 IN DRUG DEVELOPMENT K18 IN DRUG DEVELOPMENT K18 IN DRUG DEVELOPMENT
Studying Cell Death and Drug Efficacy in Rodent Xenograft Models
Human tumour xenografts are widely used as pre-clinical models for anticancer drug efficacy in humans. The M30 Apoptosense® ELISA and the M65® ELISA are human specific and thus only measure tumour cell death and not rodent liver toxicity in xenograft models, making them ideal tools for studies on pharmacodynamics and pharmacokinetics.
Cancer studies using xenograft models
The M30 Apoptosense® ELISA and the M65® ELISA in cancer studies using xenograft models
The M30 Apoptosense® ELISA and the M65® ELISA can determine tumour response in blood from xenografts, making them powerful tools for translational studies of anti-cancer drugs
The M30 Apoptosense® ELISA and the M65® ELISA measure only increases of human K18 in the blood of the rodent, as they do not cross-react with rodent proteins
The M30 Apoptosense® ELISA and the M65® ELISA are used to investigate the dose and time response of potential drug candidates prior to human trials